Type-Specific Inhibition of Preopsonization Versus Immunoprecipitation by Streptococcal M Proteins
نویسندگان
چکیده
منابع مشابه
Streptococcal M protein extracted by nonionic detergent. I. Properties of the antiphagocytic and type-specific molecules
Group A streptococcal M protein was extracted with nonionic detergent and subjected to a number of physical, chemical, and immunological tests. M protein thus extracted was composed of multiple protein bands, ranging from 35,000 down to 6,000 daltons, all having type-specific precipitating activity. The anti-phagocytic proteins, however, were limited to three molecular species having mol wt of ...
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We determined the antigenic specificity and protective immunogenicity of two chemically synthesized peptides of type 5 streptococcal M protein. The synthetic peptides, designated S-M5(1-20) and S-M5(20-40), represent the amino-terminal amino acid sequence of the native pepsin-extracted M5 molecule, which is known to contain at least one heart cross-reactive epitope. Initial studies showed that ...
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osamine bands were eluted, and the eluates were brought to dryness as described above. Separation of muramic acid from peptide. Muramic acid is usually present in smaller amounts than the other two amino sugars, and its rate of movement is sufficiently different that it is easily separated from them in the preliminary run. It has an RF value of 110 compared with glucosamine in isopropanol-water...
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We present evidence that a highly purified pepsin extract of type 5 streptococcal M protein (pep M5) contains at least three epitopes that are cross-reactive with sarcolemmal membrane proteins of human myocardium. The tissue-cross-reactive determinants of pep M5 are also partially shared with pep M6 and pep M19. Three rabbits immunized with a single 300 micrograms dose of pep M5 developed signi...
متن کاملProtective immunogenicity of group A streptococcal M-related proteins.
Many previous studies have focused on the surface M proteins of group A streptococci (GAS) as virulence determinants and protective antigens. However, the majority of GAS isolates express M-related protein (Mrp) in addition to M protein, and both have been shown to be required for optimal virulence. In the current study, we evaluated the protective immunogenicity of Mrp to determine its potenti...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1973
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.8.1.19-24.1973